Samuel married Mary Burnet Thew 15 Aug 1816. Mary (daughter of Daniel Thew and Elizabeth Burnett) was born 8 Jul 1793, Morristown, Morris County, New Jersey; died 11 Mar 1880, Cincinnati, Hamilton County, Ohio. [Group Sheet]

1. Caroline Augusta Perry was born 15 Sep 1817, Cincinnati, Hamilton County, Ohio; died 14 Nov 1891, New Haven, New Haven County, Connecticut; was buried , Cincinnati, Hamilton County, Ohio.
2. Daniel Thew Perry was born 15 Jul 1819, Cincinnati, Hamilton County, Ohio; died 18 Jul 1820, Cincinnati, Hamilton County, Ohio; was buried , Cincinnati, Hamilton County, Ohio.
3. Abraham Perry was born 15 May 1820.
4. Elizabeth Burnet Perry was born 29 Mar 1821; died 1915.
5. Samuel Perry was born 16 May 1825.
6. Mary Burnet Perry was born 1 Mar 1827.
7. Sarah Perry was born 7 Oct 1830.