Francis married Amelia Kempff 14 Jul 1864, St Louis, Missouri, USA. Amelia (daughter of Frederick Kempff and Henrietta) was born 4 Nov 1844, Belleville, St. Clair County, Illinois, USA; died 1922, Milwaukee, Milwaukee County, Wisconsin, USA; was buried , Milwaukee, Milwaukee County, Wisconsin, USA. [Group Sheet]

1. Ida Espenhain was born Apr 3 1866, Illinois; died 1948.
2. Alma J Esphenhain was born 21 Apr 1868, Belleville, St Clair, Illinois; died 26 Mar 1943, Switzerland; was buried , Montreux, District de la Riviera-Pays-d’Enhaut, Vaud, Switzerland.
3. Ella K Espenhain was born Jan 1870, Illinois; died 10 Mar 1936, Los Angeles, California, USA.
4. Irma Espenhain was born 6 Apr 1876, Bellville, Illinois; died 17 Aug 1963, Los Angeles, California; was buried , Milwaukee, Milwaukee County, Wisconsin, USA.
5. Frank Kempff Espenhain was born 28 Aug 1879, Missouri; died 1955, Dade, Florida, United States; was buried , Milwaukee, Milwaukee County, Wisconsin, USA.